MSUD (MAPLE SYRUP URINE DISEASE)
\ˈɛmsˈʌd mˈe͡ɪpə͡l sˈɪɹʌp jˈʊ͡əɹɪn dɪzˈiːz], \ˈɛmsˈʌd mˈeɪpəl sˈɪɹʌp jˈʊəɹɪn dɪzˈiːz], \ˈɛ_m_s_ˈʌ_d__ m_ˈeɪ_p_əl s_ˈɪ_ɹ_ʌ_p j_ˈʊə_ɹ_ɪ_n d_ɪ_z_ˈiː_z]\
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An autosomal recessive inherited disorder with multiple forms of phenotypic expression, caused by a defect in the oxidative decarboxylation of branched-chain ammino acids (AMINO ACIDS, BRANCHED-CHAIN). These metabolites accumulate in body fluids and render a "maple syrup" odor. The disease is divided into classic, intermediate, intermittent, and thiamine responsive subtypes. The classic form presents in the first week of life with ketoacidosis, hypoglycemia, emesis, neonatal seizures, and hypertonia. The intermediate and intermittent forms present in childhood or later with acute episodes of ataxia and vomiting. (From Adams et al., Principles of Neurology, 6th ed, p936)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.
Nearby Words
- msp1
- mspi endonuclease
- mss
- mst
- mstraiten
- MSUD (Maple Syrup Urine Disease)
- mt
- mt etna
- mt orizaba
- mt. ararat
- mt. everest