CRYPTOGENIC WEST SYNDROME
\kɹˌɪptə͡ʊd͡ʒˈɛnɪk wˈɛst sˈɪndɹə͡ʊm], \kɹˌɪptəʊdʒˈɛnɪk wˈɛst sˈɪndɹəʊm], \k_ɹ_ˌɪ_p_t_əʊ_dʒ_ˈɛ_n_ɪ_k w_ˈɛ_s_t s_ˈɪ_n_d_ɹ_əʊ_m]\
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An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.