CRYPTOGENIC PARTIAL COMPLEX EPILEPSY
\kɹˌɪptə͡ʊd͡ʒˈɛnɪk pˈɑːʃə͡l kˈɒmplɛks ˈɛpɪlˌɛpsi], \kɹˌɪptəʊdʒˈɛnɪk pˈɑːʃəl kˈɒmplɛks ˈɛpɪlˌɛpsi], \k_ɹ_ˌɪ_p_t_əʊ_dʒ_ˈɛ_n_ɪ_k p_ˈɑː_ʃ_əl k_ˈɒ_m_p_l_ɛ_k_s ˈɛ_p_ɪ_l_ˌɛ_p_s_i]\
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A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and AUTOMATISM may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.