GUIDO GUINICELLI

\ɡwˈiːdə͡ʊ ɡˌɪnɪt͡ʃˈɛli], \ɡwˈiːdə‍ʊ ɡˌɪnɪt‍ʃˈɛli], \ɡ_w_ˈiː_d_əʊ ɡ_ˌɪ_n_ɪ_tʃ_ˈɛ_l_i]\
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1910 - Warner's dictionary of authors ancient and modern
By Charles Dudley Warner

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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