THIETHYLPERAZINE
\θˈa͡ɪ͡əθɪlpəɹˌe͡ɪziːn], \θˈaɪəθɪlpəɹˌeɪziːn], \θ_ˈaɪə_θ_ɪ_l_p_ə_ɹ_ˌeɪ_z_iː_n]\
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A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.