ESKIMO DOG

\ˈɛskɪmˌə͡ʊ dˈɒɡ], \ˈɛskɪmˌə‍ʊ dˈɒɡ], \ˈɛ_s_k_ɪ_m_ˌəʊ d_ˈɒ_ɡ]\
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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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