DEFECTIVE INTERFERING PARTICLES
\dɪfˈɛktɪv ˌɪntəfˈi͡əɹɪŋ pˈɑːtɪkə͡lz], \dɪfˈɛktɪv ˌɪntəfˈiəɹɪŋ pˈɑːtɪkəlz], \d_ɪ_f_ˈɛ_k_t_ɪ_v ˌɪ_n_t_ə_f_ˈiə_ɹ_ɪ_ŋ p_ˈɑː_t_ɪ_k_əl_z]\
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Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. Some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack. Others, called SATELLITE VIRUSES, are able to replicate only when their genetic defect is complemented by a helper virus.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.