NUCLEOTIDE TRANSLOCASE
\njˈuːklɪˌɒta͡ɪd tɹanslˈɒke͡ɪs], \njˈuːklɪˌɒtaɪd tɹanslˈɒkeɪs], \n_j_ˈuː_k_l_ɪ__ˌɒ_t_aɪ_d t_ɹ_a_n_s_l_ˈɒ_k_eɪ_s]\
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An abundant mitochondrial protein and integral component of the inner mitochondrial membrane. It facilitates the exchange of ADP and ATP between the cytosol and the mitochondria, thereby linking the subcellular compartment of ATP production to those of ATP utilization. It has several known isoforms, ANT1, ANT2, & ANT3 that should not be confused with the Ant1 and Ant2 proteins that are encoded by the ant gene, which is an antirepressor gene that antagonizes the C1 repressor. EC 2.7.7.-.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.