MALARIA MENINGITIS
\malˈe͡əɹi͡ə mˌɛnɪnd͡ʒˈa͡ɪtɪs], \malˈeəɹiə mˌɛnɪndʒˈaɪtɪs], \m_a_l_ˈeə_ɹ_iə m_ˌɛ_n_ɪ_n_dʒ_ˈaɪ_t_ɪ_s]\
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A condition characterized by somnolence or coma in the presence of an acute infection with PLASMODIUM FALCIPARUM (and rarely other Plasmodium species). Initial clinical manifestations include HEADACHES, SEIZURES, and alterations of mentation followed by a rapid progression to COMA. Pathologic features include cerebral capillaries filled with parasitized erythrocytes and multiple small foci of cortical and subcortical necrosis. (From Adams et al., Principles of Neurology, 6th ed, p136)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.