MUSTARD COMPOUNDS
\mˈʌstəd kˈɒmpa͡ʊndz], \mˈʌstəd kˈɒmpaʊndz], \m_ˈʌ_s_t_ə_d k_ˈɒ_m_p_aʊ_n_d_z]\
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Strong alkylating and immunosuppressive agents whose biological activity is based on the presence of bis (2-chloroethyl)- groups. Although otherwise structurally diverse, the compounds have in common the capacity to contribute alkyl groups to DNA. They are generally highly toxic but include among their number many widely used and effective antineoplastic agents.
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Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.