DACTINOMYCIN
\dˈaktɪnˌɒmɪsˌɪn], \dˈaktɪnˌɒmɪsˌɪn], \d_ˈa_k_t_ɪ_n_ˌɒ_m_ɪ_s_ˌɪ_n]\
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An antitumor antibiotic derived from Streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.