IRRITATIVE LESION
\ˈɪɹɪtˌe͡ɪtɪv lˈiːʒən], \ˈɪɹɪtˌeɪtɪv lˈiːʒən], \ˈɪ_ɹ_ɪ_t_ˌeɪ_t_ɪ_v l_ˈiː_ʒ_ə_n]\
Definitions of IRRITATIVE LESION
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By Willam Alexander Newman Dorland
By Smith Ely Jelliffe
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.