DEMETHYL EPIPODOPHYLLOTOXIN ETHYLIDINE GLUCOSIDE
\dˈɛmiːθˌa͡ɪl ˈɛpɪpˌɒdəfˌɪlətˌɒksɪn ˈiːθɪlˌɪdiːn ɡlˈuːkəsˌa͡ɪd], \dˈɛmiːθˌaɪl ˈɛpɪpˌɒdəfˌɪlətˌɒksɪn ˈiːθɪlˌɪdiːn ɡlˈuːkəsˌaɪd], \d_ˈɛ_m_iː_θ_ˌaɪ_l ˈɛ_p_ɪ_p_ˌɒ_d_ə_f_ˌɪ_l_ə_t_ˌɒ_k_s_ɪ_n ˈiː_θ_ɪ_l_ˌɪ_d_iː_n ɡ_l_ˈuː_k_ə_s_ˌaɪ_d]\
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A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
By DataStellar Co., Ltd
Word of the day
basidiomycota
- comprises fungi bearing the spores on basidium: Gasteromycetes (puffballs); Tiliomycetes (comprising orders Ustilaginales (smuts) and Uredinales (rusts)); Hymenomycetes (mushrooms; toadstools; agarics; bracket fungi); in some classification systems considered a division of kingdom comprises fungi bearing spores on a basidium; includes Gasteromycetes (puffballs) Tiliomycetes comprising the orders Ustilaginales (smuts) and Uredinales (rusts) Hymenomycetes (mushrooms, toadstools, agarics bracket fungi).
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