APPLIER
\ɐplˈa͡ɪ͡ə], \ɐplˈaɪə], \ɐ_p_l_ˈaɪə]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.