ROD BODY MYOPATHIES
\ɹˈɒd bˈɒdi ma͡ɪˈɒpəθɪz], \ɹˈɒd bˈɒdi maɪˈɒpəθɪz], \ɹ_ˈɒ_d b_ˈɒ_d_i m_aɪ_ˈɒ_p_ə_θ_ɪ_z]\
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A group of inherited congenital myopathic conditions characterized clinically by weakness, hypotonia, and prominent hypoplasia of proximal muscles including the face. Muscle biopsy reveals large numbers of rod-shaped structures beneath the muscle fiber plasma membrane. This disorder is genetically heterogeneous and may occasionally present in adults. (Adams et al., Principles of Neurology, 6th ed, p1453)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.