HYPERBILIRUBINEMIC ENCEPHALOPATHIES
\hˌa͡ɪpəbˌɪləɹˌuːba͡ɪnˈiːmɪk ɛnsˌɛfɐlˈɒpəθɪz], \hˌaɪpəbˌɪləɹˌuːbaɪnˈiːmɪk ɛnsˌɛfɐlˈɒpəθɪz], \h_ˌaɪ_p_ə_b_ˌɪ_l_ə_ɹ_ˌuː_b_aɪ_n_ˈiː_m_ɪ_k ɛ_n_s_ˌɛ_f_ɐ_l_ˈɒ_p_ə_θ_ɪ_z]\
Sort: Oldest first
-
A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.