HOPPE-GOLDFLAM DISEASE

\hˈɒpɡˈə͡ʊldflam dɪzˈiːz], \hˈɒpɡˈə‍ʊldflam dɪzˈiːz], \h_ˈɒ_p_ɡ_ˈəʊ_l_d_f_l_a_m d_ɪ_z_ˈiː_z]\

Definitions of HOPPE-GOLDFLAM DISEASE

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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