TOPOISOMERASE IV SUBUNIT A
\tˈɒpɔ͡ɪsˌə͡ʊmɹe͡ɪz ɹˌə͡ʊmən fˈɔː sˈʌbjuːnˌɪt ˈe͡ɪ], \tˈɒpɔɪsˌəʊmɹeɪz ɹˌəʊmən fˈɔː sˈʌbjuːnˌɪt ˈeɪ], \t_ˈɒ_p_ɔɪ_s_ˌəʊ_m_ɹ_eɪ_z ɹ_ˌəʊ_m_ə_n_ f_ˈɔː s_ˈʌ_b_j_uː_n_ˌɪ_t ˈeɪ]\
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A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
Nearby Words
- topographist
- topography
- topoisomerase i
- topoisomerase ii
- topoisomerase iv
- Topoisomerase IV Subunit A
- topoisomerase iv subunit b
- topolatry
- topological space
- topology
- toponarcosis