SUPPLICATOR
\sˈʌplɪkˌe͡ɪtə], \sˈʌplɪkˌeɪtə], \s_ˈʌ_p_l_ɪ_k_ˌeɪ_t_ə]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.