MANTLE CELL LYMPHOMA
\mˈantə͡l sˈɛl lɪmfˈə͡ʊmə], \mˈantəl sˈɛl lɪmfˈəʊmə], \m_ˈa_n_t_əl s_ˈɛ_l l_ɪ_m_f_ˈəʊ_m_ə]\
Sort: Oldest first
-
A rare form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t (11;14) translocation resulting in overexpression of the cyclin D1 gene (GENES, BCL-1).
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.