JC POLYOMAVIRUS ENCEPHALOPATHY
\d͡ʒˌe͡ɪsˈiː pˌɒlɪˈɒmɐvˌa͡ɪɹəs ɛnsˌɛfɐlˈɒpəθɪ], \dʒˌeɪsˈiː pˌɒlɪˈɒmɐvˌaɪɹəs ɛnsˌɛfɐlˈɒpəθɪ], \dʒ_ˌeɪ_s_ˈiː p_ˌɒ_l_ɪ__ˈɒ_m_ɐ_v_ˌaɪ_ɹ_ə_s ɛ_n_s_ˌɛ_f_ɐ_l_ˈɒ_p_ə_θ_ɪ]\
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An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
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