ISSAYEFF'S METHOD

\ˈɪse͡ɪˌɛfs mˈɛθəd], \ˈɪse‍ɪˌɛfs mˈɛθəd], \ˈɪ_s_eɪ_ˌɛ_f_s m_ˈɛ_θ_ə_d]\

Definitions of ISSAYEFF'S METHOD

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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