AEROSPORIN
\ˈe͡əɹə͡ʊspˌɔːɹɪn], \ˈeəɹəʊspˌɔːɹɪn], \ˈeə_ɹ_əʊ_s_p_ˌɔː_ɹ_ɪ_n]\
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A mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.