ACLACINOMYCIN A
\ɐklˈasɪnˌɒmɪsˌɪn ˈe͡ɪ], \ɐklˈasɪnˌɒmɪsˌɪn ˈeɪ], \ɐ_k_l_ˈa_s_ɪ_n_ˌɒ_m_ɪ_s_ˌɪ_n ˈeɪ]\
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An anthracycline antibiotic produced by Streptomyces galilaeus. It has potent antineoplastic activity, especially in the treatment of leukemias, with reduced cardiac toxicity in comparison to daunorubicin or doxorubicin.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.